Chronic Kidney Disease Influences Multiple Systems: Describing the Relationship between Oxidative Stress, Inflammation, Kidney Damage, and Concomitant Disease

Figure 2

Interactions between radical damage, inflammation, and renal injury. Intermediates in grey initiate damage of the molecular components of renal tissue. Compounds in white, although not directly damaging, are involved in harmful reactions. Damage resulting from intermediates in grey promotes an inflammatory response during which additional superoxide is released via phagocytic NADPH oxidase activity.