Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story

Figure 1

Potential sources of reactive oxygen species (ROS) in hyperthyroid hearts: T4: thyroxin; T3: triiodothyronine; (1) mitochondria; (2) NADPH- (nicotinamide adenine dinucleotide phosphate-) oxidase; (3) NOS: nitric oxide synthase; (4) cytochrome-P450; +: activation. Representative image of thyroid gland is copied from Wikipedia under the Creative Commons Attribution-Share Alike 3.0 Unported license, which allows sharing and/or remixing. Representative images of mitochondria, NADPH-oxidase, and NOS were adapted from Novo and Parola [65]: “Redox Mechanisms in Hepatic Chronic Wound Healing and Fibrogenesis,” licensee BioMed Central Ltd. This is an open access article distributed under the terms of the , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Representative image of cytochrome-P450 is copied from Wikipedia under the terms of the GNU Free Documentation License, Version 1.2, that allows copying, distribution, and/or modification.