Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 1

NeuN and GFAP expression in the neocortex of WT and Tg mice. (a) NeuN IHC localization in the neocortex of 3-, 6-, 9-, 12-, and 18-month-old WT and Tg mice. Arrows indicate amyloid plaques in 12- and 18-month-old mice. Scale bars, 40 μm. (b) Upper picture, GFAP WB densitometric analysis on neocortex protein extracts of 3-, 6-, 9-, 12-, and 18-month-old mice. Values are expressed as mean ± SD. ; . (b) Lower pictures, GFAP IHC distribution in 6-, 9-, 12-, and 18-month-old WT and Tg neocortex. Scale bars, 60 μm.

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