Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 3

Amyloid deposits in WT and Tg neocortex. (a) Aβ IHC in 6-, 9-, and 18-month-old WT and Tg neocortex. A stronger staining is consistently present in Tg neurons, compared to WT. At late stages, Aβ accumulates within senile plaques. Scale bars, 40 μm. (b) Immunolocalization of anti-oligo-pyroGlu Aβ, revealing low molecular weight oligomers. The reaction product accumulates in Tg neocortex starting from 9 months and is observed both intra- and extracellularly, particularly inside the plaques. Scale bars, 40 μm.

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