Oxidative Stress during the Progression of <i>β</i>-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

<div>Expression of oxidative damage markers in WT and Tg neocortex. (a) 8-OHG IHC in 3-, 9-, and 18-month-old WT and Tg neocortex. Prominent cytoplasmic staining in Tg neurons is observed throughout the ages. Scale bars, 30 <i>μ</i>m. (b) Acrolein IHC showing higher levels in Tg than in WT neurons, starting from the age of 9 months. Scale bars, 30 <i>μ</i>m. (c) Double immunofluorescence of 8-OHG (red) in combination with SOD2 (green) in the neocortex of 3-month-old Tg mice, showing partial colocalization of both markers, thus indicating mitochondrial DNA oxidative modifications. Scale bars, 30 <i>μ</i>m.</div>

Oxidative Medicine and Cellular Longevity

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Figure 5

Figure 5: Oxidative Stress during the Progression of <i>β</i>-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease 

Oxidative Medicine and Cellular Longevity

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 5