Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease

Table 1

Genes identified in SHRSP in relation to increased susceptibility to vascular damage.

Gene name	Experimental context	Reference
Ndufc2	Salt loading (brain)	[13]
UCP2	Salt loading (kidneys)	[14]
Mit HMG-CoA synthase	Standard chow (kidneys)	[33]
Nrf2	Standard chow (arteries and VSMC)	[12]
Agt	Standard chow (adrenal glands, kidneys, brain)	[38
Stim1	Exaggerated sympathetic response to stress	[34]
Atrial natriureticpeptide	Salt loading (brain)	[35, 36]
MMP14	Gene expression analysis of brain SVD	[37]
Gnai1	Gene expression analysis of brain SVD	[39
Vasopressin	Gene expression analysis of brain SVD	[37]
Albumin	Gene expression analysis of brain SVD	[37]
NO receptor	Gene expression analysis of brain SVD	[37]
Gucy1a3	Gene expression analysis of brain SVD	[37]
Rps9	Gene expression analysis of brain SVD	[37]
Edg1	Salt loading (kidneys)	[38]
Vcam1	Salt loading (kidneys)	[38]

Mit HMG-CoA: mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A; Gnai1: guanine nucleotide binding protein alpha inhibitor 1; Nrf2: nuclear factor erythroid 2-related factor; Agt: angiotensinogen; Stim1: stromal interaction molecule 1; NO: nitric oxide; MMP14: metalloproteinase 14; Rps9: ribosomal protein S9; Gucy1a3: guanylate cyclase 1, soluble, alpha 3; Edg1: endothelial differentiation gene receptor 1; Vcam1: vascular cell adhesion molecule 1; SVD: small vessel disease.