Review Article
Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease
Table 1
Genes identified in SHRSP in relation to increased susceptibility to vascular damage.
| Gene name | Experimental context | Reference |
| Ndufc2 | Salt loading (brain) | [13] | UCP2 | Salt loading (kidneys) | [14] | Mit HMG-CoA synthase | Standard chow (kidneys) | [33] | Nrf2 | Standard chow (arteries and VSMC) | [12] | Agt | Standard chow (adrenal glands, kidneys, brain) | [38 | Stim1 | Exaggerated sympathetic response to stress | [34] | Atrial natriureticpeptide | Salt loading (brain) | [35, 36] | MMP14 | Gene expression analysis of brain SVD | [37] | Gnai1 | Gene expression analysis of brain SVD | [39 | Vasopressin | Gene expression analysis of brain SVD | [37] | Albumin | Gene expression analysis of brain SVD | [37] | NO receptor | Gene expression analysis of brain SVD | [37] | Gucy1a3 | Gene expression analysis of brain SVD | [37] | Rps9 | Gene expression analysis of brain SVD | [37] | Edg1 | Salt loading (kidneys) | [38] | Vcam1 | Salt loading (kidneys) | [38] |
|
|
Mit HMG-CoA: mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A; Gnai1: guanine nucleotide binding protein alpha inhibitor 1; Nrf2: nuclear factor erythroid 2-related factor; Agt: angiotensinogen; Stim1: stromal interaction molecule 1; NO: nitric oxide; MMP14: metalloproteinase 14; Rps9: ribosomal protein S9; Gucy1a3: guanylate cyclase 1, soluble, alpha 3; Edg1: endothelial differentiation gene receptor 1; Vcam1: vascular cell adhesion molecule 1; SVD: small vessel disease.
|