Research Article
A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study
Table 3
Unadjusted and adjusted linear mixed models of LVMI and LVEF through follow-up (longitudinal analysis).
(a) LVMI model |
| Variables (units of increase) | Model 1 (unadjusted) | Model 2 | b | P value | b | P value |
| PON1 (Q192R) | 13.40 (4.17 to 22.62) | 0.005 | 9.24 (0.51 to 17.96) | 0.04 | HDL (1 mg/dL) | | | −0.44 (−0.86 to −0.02) | 0.04 | eGFR MDRD186 (1 mL/min/1.73 m2) | | | −0.46 (−0.64 to −0.28) | <0.001 |
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(b) LVEF model |
| Variables (units of increase) | Model 1 (unadjusted) | Model 2 | b | P value | b | P value |
| PON1 (Q192R) | −2.96 (−4.62 to −1.29) | 0.001 | −2.84 (−4.54 to −1.15) | 0.001 | HDL (1 mg/dL) | | | 0.07 (−0.01 to 0.15) | 0.08 | eGFR MDRD186 (1 mL/min/1.73 m2) | | | −0.02 (−0.05 to 0.01) | 0.23 |
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Data are expressed as estimate of fixed effects (b), 95% confidence interval, and P value.
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