Differential Regulation of the Extracellular Cysteine/Cystine Redox State (E_hCySS) by Lung Fibroblasts from Young and Old Mice

Table 1

Differential expression of genes related to Cys and CySS transporters and glutathione-related thiol-disulfide enzymes.

Gene	Old versus young; (fold-difference)	Step-up; value
Cys and CySS transporters
Slc7a11	Down 5.0-fold	0.0034
Slc7a9		0.28
Slc1a1		0.85
Slc1a4	Down 1.5-fold	0.034
Slc1a5		0.092
Slc3a1		0.38
Slc3a2		0.69
Thiol-disulfide enzymes: Glutathione-related
Gpx1	Up 1.4-fold	0.033
Gpx2		0.096
Gpx3		0.49
Gpx4		0.064
Gpx5		0.87
Gpx6		0.71
Gpx7		0.067
Gpx8		0.23
Gsr		0.54
Gclc		0.62
Gclm		0.60
Gss		0.48
Glrx	Down 1.7-fold	0.0097
Glrx2		0.11
Glrx3	Up 1.4-fold	0.044
Glrx5	Up 1.2-fold	0.048

Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
Step-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.