Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Figure 2

NO action in oocyte activation is evolutionary inconsistent. The NO/sCG/cGMP/PKG signal pathways are presumed, where dual NO effect on sCG, resulting in its S-nitrosylation and NO binding, is expectable. Obviously, dependency of fertilization and oocyte activation, followed by cleavage and the second polar bod extrusion, is shaded in evolutionary more developed organisms, where fulfilment of certain conditions (Ca²⁺ presence, pulsative character of NO) is necessary.