Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats

Figure 7

(a) Western blotting was performed to evaluate the activation levels of p-ERK1/2, p-CREB, Bcl-2, and Bax. The levels of p-ERK1/2 (b), p-CREB (c), Bcl-2 (d), Bax (e), and cleaved caspase-3 (f) are expressed as mean ± SD; . (g) Western blotting was performed to evaluate the activation levels of p-ERK1/2, p-CREB, Bcl-2, and Bax. The levels of p-ERK1/2 (h), p-CREB (i), Bcl-2 (j), Bax (k), and cleaved caspase-3 (l) are expressed as mean ± SD; ( versus sham group; versus saline group; versus TK group; versus B1RA+TK group; versus B2RA+TK group).

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