Review Article
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress
Table 3
Modulation of ROS formation in BAECs by CA (DHPs and verapamil) and vitamin E. Compiled according to data presented by Cominacini et al. [
123].
| Compound | Method of flow cytometry (reduced 2,7-dichlorofluorescein diacetate (DCFH-DA) oxidation by ROS) | Activity rank order (ARO = I for the highest activity; ARO = III for the mindest activity) (Effective [IC]: 1; 5; 10; 50 M) |
| Lacidipine | + + + (ARO = I) | Lercanidipine | + + (ARO = II) | Amlodipine | No effect | Nifedipine | No effect | Nimodipine | No effect | Verapamil | + (ARO = III) | -Tocopherol | + + + (ARO = I) |
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