Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats

Figure 1

Effect of Fisetin on histopathology of HCC liver. Representative photomicrographs of liver sections from control (C), HCC, and HCC + F groups at 10 W stage have been shown. In (a), upper panel shows 10x magnification with scale bar of 200 μm and lower panel shows 40x magnification with scale bar of 50 μm. Dotted line encircles FAH area as a mark of neoplastic lesion. (b) shows level of GST-pi in the liver from control, HCC, and Fisetin treated HCC rats, wherein liver extract containing 60 µg protein in each lane was subjected to 10% SDS-PAGE followed by western transfer and detection of GST-pi bands against a polyclonal anti-GST-pi. The photograph is representative of the three western blot repeats. Normalized densitometry values of GST-pi/β-actin have been presented as mean ± SD from three western repeats. (control versus HCC group) and (HCC versus HCC + F group).

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