The Impact of Lipoprotein-Associated Oxidative Stress on Cell-Specific Microvesicle Release in Patients with Familial Hypercholesterolemia
Table 1
Characteristics of study participants.
Characteristics
Controls
FH
value
FH ATX−
FH ATX+
value
Men/women
8/15
12/18
NS
7/7
5/11
NS
Age (years)
47.0 ± 10.1
45.5 ± 9.1
NS
43.1 ± 10.2
47.5 ± 7.8
NS
BMI (kg/m2)
23.7 ± 3.3
25.5 ± 5.2
NS
25.1 ± 4.2
25.9 ± 5.9
NS
Systolic b.p. (mm Hg)
120.2 ± 10.8
124.9 ± 14.3
NS
122.4 ± 13.7
127.1 ± 14.8
NS
Diastolic b.p. (mm Hg)
74.6 ± 6.7
77.4 ± 6.5
NS
76.0 ± 5.5
78.7 ± 7.1
NS
Platelet count (109/L)
239.8 ± 50.7
248.6 ± 60.1
NS
247 ± 55.7
250 ± 65.4
NS
Leukocyte count (109/L)
5.1 ± 1.2
5.4 ± 1.9
NS
5.0 ± 1.6
5.7 ± 2.2
NS
Monocyte count (109/L)
0.4 ± 0.1
0.5 ± 0.1
NS
0.4 ± 0.1
0.5 ± 0.2
NS
Hemoglobin (mmol/L)
8.7 ± 0.6
9.0 ± 0.8
NS
9.1 ± 1.0
8.9 ± 0.7
NS
Total-C (mmol/L)
5.1 ± 0.7
9.1 ± 1.8
<0.0001
8.2 ± 1.1
9.9 ± 2.0
0.0098
LDL-C (mmol/L)
2.9 ± 0.5
7.0 ± 1.8
<0.0001
6.0 ± 1.1
7.9 ± 1.8
0.0025
HDL-C (mmol/L)
1.7 ± 0.4
1.5 ± 0.4
0.014
1.5 ± 0.5
1.4 ± 0.4
NS
oxLDL-C (U/L)
50.0 ± 11.8
100.3 ± 24.2
<0.0001
83.7 ± 13.6
114.8 ± 22.1
0.0001
ApoB (g/L)
0.8 ± 0.1
1.7 ± 0.4
<0.0001
1.4 ± 0.3
1.8 ± 0.3
0.0015
Glucose (mmol/L)
5.4 ± 0.5
5.5 ± 0.4
NS
5.5 ± 0.4
5.5 ± 0.4
NS
ALT (U/L)
19.0 (14.0–21.0)
19.0 (17.0–34.0)
NS
20.5 (18–32)
18.5 (15.0–36.5)
NS
TG (mmol/L)
1.0 (0.8–1.2)
1.1 (0.8–1.8)
NS
1.3 (0.7–1.8)
1.1 (1.0–1.6)
NS
Normal and nonnormal distributions are shown as the mean ± standard deviation and as the median (interquartile range), respectively. Controls versus FH subjects; FH subjects without ATX versus FH subjects with ATX. BMI, body mass index; ALT, alanine-aminotransferase, TG, triglycerides; ApoB, apolipoprotein B; Total-C, total cholesterol; LDL-C, LDL-cholesterol; HDL-C, HDL-cholesterol; oxLDL-C, oxidized LDL-C; b.p., blood pressure; NS, nonsignificant.
