From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia

Table 2

AML patient characteristics according to the CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTP1 Ile105Val, GSTM1,and GSTT1 genotypes.

	CAT C262T			GPX1 Pro198Leu			MnSOD Ala16Val			GSTP1 Ile105Val			GSTM1			GSTT1
	CC	CT + TT	value	Pro/Pro	Pro/Leu + Leu/Leu	value	Ala/Ala	Ala/Val + Val/Val	value	Ile/Ile	Ile/Val + Val/Val	value	Present	null	value	Present	null	value
Gender
Female	22	24	Ref	0	46	Ref	13	33	Ref	23	23	Ref	18	28	Ref	36	10	Ref
Male	33	23	0.264	3	53	0.055	11	45	0.308	16	40	0.026	25	31	0.574	42	14	0.699
Age
60 years	37	31	Ref	1	67	Ref	17	51	Ref	24	44	Ref	24	44	Ref	53	15	Ref
60 years	18	16	0.888	2	32	0.257	7	27	0.805	15	19	0.387	19	15	0.057	25	9	0.805
Age (median, range)
50 years	27	20	Ref	1	46	Ref	13	34	Ref	16	31	Ref	17	30	Ref	35	12	Ref
50 years	28	27	0.554	2	53	1.00	11	44	0.483	23	32	0.540	26	29	0.316	43	12	0.815
FAB classification			0.698			0.565			0.014			0.333			0.149			0.461
M0	2	4		0	6		2	4		2	4		1	5		6	0
M1	15	10		2	23		2	23		10	15		10	15		18	7
M2	16	10		0	26		10	16		5	21		12	14		19	7
M3	2	1		0	3		1	2		1	2		1	2		3	0
M4	11	8		0	19		6	13		11	8		5	14		16	3
M5	6	9		1	14		0	15		6	9		11	4		10	5
M6	1	3		0	4		1	3		2	2		1	3		3	1
M7	2	2		0	4		2	2		2	2		2	2		3	1
Cytogenetic risk group			0.058			0.549			0.067			0.925			0.630			0.194
Favorable	6	6	Ref	0	12	Ref	4	8	Ref	4	8	Ref	6	6	Ref	11	1	Ref
Intermediate	38	26	0.751	2	62	1.00	11	53	0.238	25	39	1.00	27	37	0.753	48	16	0.279
Unfavorable	2	8	0.204	0	10	—	5	5	0.665	4	6	1.00	3	7	0.730	6	4	0.136
ND	9	7	1.00	1	15	1.00	4	12	0.691	6	10	1.00	7	9	1.00	13	3	0.613
FLT3 mutations
FLT3−	40	38	Ref	3	75	Ref	17	61	Ref	31	47	Ref	36	42	Ref	57	21	Ref
FLT3+	15	9	0.93	0	24	1.00	7	17	0.457	8	16	0.572	7	17	0.141	21	3	0.145
DNMT3A mutations
DNMT3A−	48	42	Ref	2	88	Ref	21	69	Ref	31	59	Ref	39	51	Ref	69	21	Ref
DNMT3A+	7	5	0.744	1	11	0.316	3	9	1.00	8	4	0.054	4	8	0.510	9	3	1.00

ND: not determined; Ref: reference.