Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms

Table 3

Summary of studies investigating the role of melatonin and its receptors in LTP and learning and memory processes.

Experimental approach	LTP	Main findings	MT receptor involved	Ref.
Melatonin 1 nM	Inhibits	Melatonin inhibits via MT2.	MT2	[166]
Melatonin 0.1 to 2.0 mM	Inhibits	Luzindole, an antagonist of MT receptors, blocks the inhibitory effect.	MT	[167]
Melatonin 100 M	Inhibits	BMNEP, a specific ligand of the MT2 receptors, mimics the inhibitory action.	MT2	[168]
Melatonin 0.1 nM to 100 M; mice and mice	Inhibits	Melatonin inhibitory action is prevented by luzindole and 2-propionamidotetraline, an MT2 antagonist.; mice lost inhibitory effect on LTP, but not mice.	MT2	[169]
mice	Inhibits	Slices from mice exhibited smaller and decrement LTP compared to wild type mice.; mice showed impairment in the EPM on 2 consecutive days.	MT2	[170]
MT1/ mice	Enhances	MT1/ mice demonstrated improvement in cognitive performance in the Barnes- and Y-maze tests.	MT1/MT2	[171]