ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

Figure 1

Schematic representation of ROS signaling in physiological and pathological conditions. Low and medium ROS levels produced by mitochondria and NADPH oxidase activate cell ROS sensitive proteins and epigenetic machinery. High ROS level causes nucleic acids, lipid, and proteins damage possibly involved in accelerated aging, cell death, and age-related diseases.