The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

Table 2

HIF-dependent genes in hypoxia adaptation in determining malignancy hallmarks.

HIF-dependent genes	Adaptation phenotype	ROS effect	References
VEGFs and VEGFRs	Neoangiogenesis, repair	Indirect	[63–65]
TERT (telomerase)	telomere length and proliferative potential	Direct and indirect	[66–69]
Cyclin D1, cyclin D2	Increased proliferation	Indirect	[70]
TERT; c-Myc, SOX2, OCT4, KLF4, Notch	Stem cell renewal, differentiated cell reprogramming	Indirect	[71, 72]
ABC transporter	Drug resistance	Indirect	[75–77]
ALDA, PGK, GLUT-1	Changes in energy metabolism	Indirect	[61, 78]
PDGF, chemokine receptors	Motility and polarized migration	Indirect	[104, 105]
MMP9, MMPs	Integrity of basement membrane; invasiveness	Direct and indirect	[97–100]
Alarmin (DAMPs) receptors	NFκB activation; IRR gene express	Indirect	[80–82]