Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin

Figure 1

The effect of quercetin and DFO on the mice liver oxidative damage delivered by chronic alcohol consumption. The liver MDA (a) and the ratio of GSH/GSSH (b) were detected by spectrophotometry. Each value represents the mean ± SD (). Liver ROS (c) was detected and visualized with fluorescence microscope (×100). Fluorescence intensities in randomly selected areas of the images were quantified with IPP 6.0 image analysis software (d). C: control; E: ethanol; EQ: ethanol plus quercetin; ED: ethanol plus DFO; Q: quercetin; D: DFO. A: versus the control; B: versus the ethanol group.

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