Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin

Table 1

Effects of quercetin on body weights and liver ratio to weight in the mice chronically fed ethanol for 15 weeks.

	Initial weight (g)	Final weight (g)	Weight gain (g)	Liver ratio to weight %
C	18.4 ± 1.1	28.9 ± 1.1	10.7 ± 2.2	4.6 ± 0.6
E	18.3 ± 1.2	23.1 ± 2.1	4.8 ± 1.8	5.8 ± 0.5
EQ	18.5 ± 1.2	25.4 ± 1.8	6.9 ± 1.9	4.9 ± 0.4
Q	18.4 ± 1.1	29.0 ± 1.5	10.6 ± 2.1	4.6 ± 0.3
ED	18.3 ± 1.1	24.1 ± 2.1	5.9 ± 1.9	5.3 ± 0.4
D	18.4 ± 1.1	26.8 ± 1.6	8.4 ± 1.7	4.7 ± 0.5

The male C57BL/6J mice were pair-fed with either regular or ethanol-containing Lieber De Carli liquids diets for 15 weeks. Quercetin and DFO were received by gavage and intraperitoneal injections, respectively, according to the body weight. Data were shown as mean ± SD, . versus control; versus ethanol. C: control; E: ethanol; EQ: ethanol plus quercetin; ED: ethanol plus DFO; Q: quercetin; D: DFO.