Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis

Figure 1

Pin1 expression and activity were upregulated by alcohol treatment of cardiomyocytes. (a) qRT-PCR of Pin1 mRNA expression in cardiomyocytes treated with alcohol (0, 50, 100, or 200 mM) for 24 h. (b) Western blot of Pin1 expression in cardiomyocytes treated with alcohol at indicated concentrations. (c) Pin1 activity assays in cardiomyocytes treated with alcohol at indicated concentrations. and compared to cells without alcohol treatment.

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