Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis

Figure 2

Knockdown of Pin1 inhibited alcohol-induced cardiomyocyte apoptosis. (a) Pin1 protein expression measured by western blotting after Pin1 siRNA transfection. ((b)–(d)) Cell viability assay (b), caspase-9 and caspase-3 activity assays (c), and TUNEL staining (d) in Pin1-knockdown cardiomyocytes treated or untreated with alcohol (200 mM) for 24 h. , , and .

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