The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity

Figure 2

Oxidative stress-induced lysosomal genes expression. (a, b) SHY5Y cells or primary neurons were treated with H₂O₂ for 4 h and lysosomal gene levels were analysed by RT-PCR. Values are the means ± SEM. compared with the H₂O group. (c) SHY5Y cells were treated with different concentrations of H₂O₂ and the lysosomal enzyme cathepsin D was detected by western blot analysis. (d) Lysosomal genes of brains treated with or without MPTP were analysed by RT-PCR. Values are the means ± SEM. , , and compared with the saline group.

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