The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity

Figure 8

C-ETS2 mediates the expression of lysosomal genes induced by oxidative stress. (a) C-ETS2 was overexpressed in 293T cells and lysosomal genes were detected via RT-PCR. Values are the means ± SEM. compared with the empty vector group. (b) 293T cells were infected with different amounts of the C-ETS2-knockdown adenovirus, and lysosomal genes were detected via RT-PCR. Values are the means ± SEM. , compared with the GFP virus group. (c, d) SHY5Y cells and primary neurons were infected with the C-ETS2-knockdown adenovirus and the lentivirus, respectively, under oxidative stress and lysosomal genes were detected via RT-PCR. Values are the means ± SEM. , compared with the GFP virus group in (c); , , and compared with the control lentivirus group after H₂O or H₂O₂ treatment, respectively, in (d).

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