Redox Modulations, Antioxidants, and Neuropsychiatric Disorders

Figure 3

Mechanisms of Nrf2 activation and degradation. ROS, reactive oxygen species; RNS, reactive nitrogen species; Nrf2, nuclear factor- (erythroid-derived-2-) like 2; Keap1, Kelch-like ECH-associated protein 1; DAG, diacylglycerol; PKC, protein kinase C; Bach1, transcription regulator protein BACH1; Maf, transcription factor Maf; ARE, antioxidant response elements; GCL, glutamate-cysteine ligase; GST, glutathione-S-transferase; NQO1, NADPH:quinone oxidoreductase 1; HMOX, heme oxygenase; Ub, ubiquitin.