Erectile Dysfunction Drugs Changed the Protein Expressions and Activities of Drug-Metabolising Enzymes in the Liver of Male Rats

Figure 1

Western immunoblotting showed the influence of tadalafil, vardenafil, and sildenafil on the expression of CYP2E1, CYP1A2, cyt. c reductase, CYP2B1/2, CYP3A4, CYP2C23, and CYP2C6, respectively. Lane A is microsomal protein of matched control groups. Lanes B and C are microsomal proteins of rats treated with low and high doses of tadalafil; lanes D and E are microsomal proteins of rats treated with low and high doses of vardenafil; lanes F and G are microsomal proteins of rats treated with low and high doses of sildenafil, respectively.