Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator

Figure 3

Correlation of mitochondrial DNA methylation with insulin sensitivity (HOMA-IR and FI) and current diagnostic indices (FG and A1c). (a-b) HOMA-IR and FI showed significant interaction with ND6 methylation; . (c) FG showed no correlation with ND6 methylation; . (d) A1c showed no correlation with ND6 methylation; . (e) HOMA-IR showed significant interaction with D-loop methylation; . (f) FG showed no correlation with D-loop methylation; . (g) A1c showed no correlation with D-loop methylation; . (h) Cholesterol showed no correlation with D-loop methylation; . More details about correlation of DNA methylation in mitochondrial D-loop with lipid profile can be found in Supplemental Figure  4.

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