Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse

Figure 1

Nitric oxide profile and posttranslational modifications. This figure indicates pathways of NO generation and posttranslational modifications. (a) Generation of NO by the three different NO synthases leads to activation of the sGC and thiol nitrosylation forming S-nitrosothiols. Further reaction of NO with oxygen radicals leads to the formation of peroxynitrite and subsequent irreversible modification of tyrosine residues. (b) Concentration dependency between NO levels and the amount of posttranslational modifications with associated dominance of prosurvival or prodeath signalling.

(a)

(b)