Mitochondrial Alterations in Peripheral Mononuclear Blood Cells from Alzheimer’s Disease and Mild Cognitive Impairment Patients

Figure 4

mtDNA copy content in PBMCs derived from AD, MCI patients and healthy controls. mtDNA content was measured as the amount of cytochrome B copy number (mitochondrial DNA) normalized to 36B4 gene copy number (nuclear DNA) by real time PCR in Spanish (a) and Italian (b) DNA samples. Data was expressed as mean ± SEM. The statistical significance was represented by the asterisks as follows: ; versus the corresponding control group. The values of mtDNA content of both Spanish and Italian cohort were also correlated with the corresponding values of MMSE score (c). mtDNA content/MMSE ( and ).

(a)

(b)

(c)