A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal

Figure 1

The urinary 8-oxo-dGuo levels (a) and plasma antioxidant defense status [CAT (b), GPx (c), NQO1 (d), and total SOD (e) activities and GSH levels (f)] in control subjects and BCC patients before and after surgery. Values given are mean ± SD. The statistical significance of differences between the control and case was evaluated by one-way ANOVA followed by Tukey’s post hoc test. compared to preoperative values in control subjects prior to surgery; compared to preoperative values in BCC patients prior to surgery. Principal component analysis was performed to systematically investigate similarity of DNA damage and antioxidant defense parameters from different groups of patients (g). Factor analysis is overlaid on top of the patient scores, both before surgery (case: triangle; control: square) and 1 month after surgery (case: circle; control: plus). The dashed and dotted ovals delineate the approximated distribution of each group with 95% confidence intervals.

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