Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKL/OPG Ratio in Postmenopausal Women with Osteopenia
Table 1
Principal characteristics of normal, osteopenic, and osteoporotic postmenopausal women.
Normal BMD
Osteopenia
Osteoporosis
Statistics
()
()
()
Age, yr
54.0 ± 4.2
56.2 ± 4.5
57.7 ± 4.7
0.01
Years since menopause, yr
3 (1–9)
5 (2–10)
7 (4–12)
0.09#
BMI, kg/m2
24.2 (23.0–27.4)
23.1 (21.5–27.3)
23.2 (22.1–26.7)
0.16#
Waist circumference, cm
85.9 ± 10.9
83.2 ± 8.4
82.5 ± 8.9
0.05
DXA parameters
L. spine BMD, g/cm2
1.10 ± 0.91
0.92 ± 0.11
0.83 ± 0.09
<0.01
L. spine -score
0.1 (−0.6 to 0.3)
−1.8 (−2.1 to −1.2)
−2.5 (−2.8 to −1.8)
<0.01#
F. neck BMD, g/cm2
0.81 (0.79–0.86)
0.67 (0.63–0.71)
0.62 (0.57–0.64)
<0.01#
F. neck -score
−0.3 (−0.6 to 0.0)
−1.6 (−2.0 to −1.2)
−2.1 (−2.5 to −1.8)
<0.01#
Total hip BMD, g/cm2
0.93 ± 0.08
0.81 ± 0.07
0.74 ± 0.07
<0.01
Total hip -score
−0.1 (−0.4 to 0.4)
−1.1 (−1.5 to −0.8)
−1.5 (−2.0 to −1.2)
<0.01#
Biochemical markers
Hs-CRP, mg/L
1.5 (0.6–3.7)
1.1 (0.6–2.1)
1.2 (0.4–2.6)
0.54
CTX-1, ng/mL
0.47 ± 0.21
0.46 ± 0.39
0.52 ± 0.30
0.47
BAP, g/L
30.3 ± 1.3
31.0 ± 1.0
25.1 ± 1.3
0.24
RANKL, pmol/L
270 (201–362)
255 (157–347)
281 (166–365)
0.18#
OPG, pmol/L
8.1 (7.3–10.6)
11.0 (6.9–16.6)
12.0 (5.7–18.6)
0.78#
RANKL/OPG
31.0 (18.2–64.1)
20.1 (11.5–60.1)
21.2 (11.4–34.2)
0.31#
8-OHdG, ng/mg creatinine
143 (109–189)
154 (109–208)
159 (112–212)
0.35#
Data presented are expressed as mean ± standard deviation for normally distributed variables; median (interquartile range) for not normally distributed variables. value by Kruskal-Wallis; # value by ANOVA. BMI: body mass index; BMD: bone mass density; L.: lumbar; F.: femoral; Hs-CRP: high reactivity C-reactive protein; CTX-1: C-terminal telopeptide of type I collagen; BAP: bone-specific alkaline phosphatase; OPG: osteoprotegerin; RANKL: receptor activator of nuclear factor kappa-B ligand; 8-OHdG: 8-hydroxy-2′-deoxyguanosine.
