Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKL/OPG Ratio in Postmenopausal Women with Osteopenia

Table 4

Multiple regression analysis for the relationship between 8-OHdG and RANKL and RANKL/OPG, among osteopenic postmenopausal women ().

Predictors	Dependent variable		Dependent variable
	RANKL		RANKL/OPG
	Beta	value	Beta	value
8-OHdG	0.469	0.002	0.449	0.004
Age	0.071	0.694	0.119	0.644
Years since menopause	0.031	0.849	0.015	0.930
BMI	0.016	0.939	0.059	0.274
Waist circumference	0.001	0.998	−0.049	0.812
Hs-CRP	−0.115	0.411	−0.079	0.523

Beta: standardized regression coefficient; BMI: body mass index; BMD: bone mass density; Hs-CRP: high reactivity C-reactive protein; RANKL: receptor activator of nuclear factor kappa-B ligand; 8-OHdG: 8-hydroxy-2′-deoxyguanosine.