Decavanadate Toxicology and Pharmacological Activities: V₁₀ or V₁, Both or None?

Figure 1

Mitochondria: a target for decavanadate (V₁₀). Oxygen consumption and membrane depolarization are strongly affected whereas no effects were found for MTP and ATP synthase. To our knowledge, V₁₀ effects on Ca²⁺ uniporter and Na⁺/Ca²⁺ exchanger were not yet described. F₁F₀, F₁F₀-ATP synthase; e.t.c., electron transport chain; mCU, Ca²⁺ uniporter; NCx, Na⁺/Ca²⁺ exchanger; MTP, mitochondrial transition pore; , membrane potential.