Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2

Table 1

Scheme of the experiment to study the protective role of GSPB2 in diquat-induced oxidative damage.

Group	Treated with	Treatment time
Control (I)	Saline (orally, once daily)	21 days
Control + GSPB2 (II)	GSPB2 (30 mg/kg, orally, once daily)	21 days
Diquat (III)	Saline (as in group I) + diquat (8 mg/kg, i.p. twice weekly)	Saline treatment for 7 days and then treatment with diquat for two weeks
Diquat + GSPB2 (IV)	GSPB2 (as in group II) + diquat (as in group III)	GSPB2 treatment for 21 days, on day 7, treated with diquat for two weeks