Bach1 Induces Endothelial Cell Apoptosis and Cell-Cycle Arrest through ROS Generation

Figure 7

Mechanisms for the Bach1-induced cell-cycle arrest and apoptosis in ECs. Bach1 induces caspase 3-dependent apoptosis by ROS production in ECs; Bach1 also regulates the expression of cell-cycle regulatory proteins (cyclin D1 and cyclin E2) and promotes cell-cycle arrest through ROS generation.