Redox Imbalance and Viral Infections in Neurodegenerative Diseases

Figure 2

Different genetic and/or environmental factors lead to ROS increase during neurodegeneration. This accumulation triggered the activation of glia cells and the release of proinflammatory markers, stimulating thus a neuroinflammatory response. These events contribute to neuronal damage (DNA damage, lipid peroxidation, and protein oxidation) and axon degeneration, which ultimately caused neuronal death. In addition, virus infection can strengthen the ROS-mediated neurodegenerative signs in neurons and glia cells, producing functional and molecular hallmarks of neurodegeneration.