In Vivo Effects of Vanadium Pentoxide and Antioxidants (Ascorbic Acid and Alpha-Tocopherol) on Apoptotic, Cytotoxic, and Genotoxic Damage in Peripheral Blood of Mice

Table 2

Averages of the PCE/NCE ratio in peripheral blood of mice.

Treatment	Dose (mg/kg)		Time analysis (hours)	PCE/NCE 1,000 cells^∧ (mean ± SD)	ANOVA
Control (water)	0	5	0	127.4 ± 5.9
			24	123.2 ± 11.2
			48	133.6 ± 10.1
			72	128.8 ± 4.9
Control (corn oil)	0	5	0	115.0 ± 3.9
			24	115.5 ± 4.0
			48	111.7 ± 3.4
			72	114.0 ± 2.2
AA	100	5	0	100.6 ± 2.0
			24	68.8 ± 1.9	a, b
			48	67.2 ± 3.0	a, b
			72	68.2 ± 0.8	a, b
α-TOH	20	5	0	103.4 ± 3.6
			24	75.4 ± 3.4	a, c
			48	66.2 ± 7.0	a, c
			72	67.8 ± 2.4	a, c
V2O5	40	5	0	123.8 ± 6.6
			24	125.4 ± 4.2	d, f
			48	124.8 ± 4.3	d, f
			72	136.6 ± 3.0	d, f
AA + V2O5	100 + 40	5	0	101.2 ± 4.7
			24	95.8 ± 5.3	a
			48	88.4 ± 1.3	a
			72	87.6 ± 1.9	a
α-TOH + V2O5	20 + 40	5	0	116.0 ± 4.4
			24	87.0 ± 3.4	a, e
			48	84.6 ± 3.4	a, e
			72	87.4 ± 2.2	a, e

⁢ versus control; versus AA 0 h; versus α-TOH 0 h; versus AA + V₂O₅; versus AA + V₂O₅ 0 h; versus α-TOH + V₂O₅.
AA: vehicle water, distilled; α-TOH: vehicle corn oil.
^∧1,000 erythrocytes were evaluated in each mouse (5 mice per group).