Genome-Wide Transcriptional Analysis Reveals the Protection against Hypoxia-Induced Oxidative Injury in the Intestine of Tibetans via the Inhibition of GRB2/EGFR/PTPN11 Pathways
Table 1
The baseline characters of all participants.
Characteristic
Han Chinese
Tibetans
-ratio
value
Group I
Group II
Group I
Group II
Age (years)
41–45
40–49
40–45
39–48
0.38
0.77
Smoking (no/yes)
1/2
3/4
1/2
2/5
1.77
0.29
Drinking (no/yes)
1/2
3/4
1/2
2/5
1.77
0.29
Gender (male/female)
2/1
5/2
2/1
4/3
1.77
0.29
BMI
29–34
28–35
30–33
27–36
0.26
0.29
Food calorie intake (kcal/d)
2545.4–2089.3
2435.6–2132.7
2533.8–2134.7
2510.6–2184.1
0.85
0.36
Frequency of food (per day)
3 times
3 times
3 times
3 times
0
1
Habit
Rural
Rural
Rural
Rural
—
—
Marital status
Married
Married
Married
Married
—
—
Physical activity
Routine work
Routine work
Routine work
Routine work
—
—
Emotional makeup
Normal
Normal
Normal
Normal
—
—
Sleep habits
Day
Day
Day
Day
—
—
Mental stress
Social
Social
Social
Social
—
—
Water intake
During meal
During meal
During meal
During meal
—
—
Diet and sleep timings
Regular
Regular
Regular
Regular
—
—
Living at altitude (meters)
100
100
3650–3690
3650–3690
297.3160
<0.0001
Time at plain area or high altitude (years)
41–45
40–46
40–45
42–44
1.54
0.28
Hb (g/L)
144–156
140–160
166–175
165–180
2.56
0.04
Systolic pressure (mmHg)
112–124
108–129
125–130
122–138
2.20
0.03
Diastolic pressure (mmHg)
68–78
65–80
82–89
80–92
3.62
0.01
Blood oxygen saturation (%)
98-99
98-99
82–85
80–86
5.36
0.01
Heart rate (time/mini)
64–78
60–80
78–87
78–90
2.04
0.06
Note: BMI, body mass index; Hb, hemoglobin. There is a significant difference if < 0.05. Group I, the participants underwent genome-wide transcriptional analysis, real-time PCR, and Western Blot analysis. Group II, the participants underwent real-time PCR and Western Blot analysis.
