Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway

Figure 2

ZYZ-803 could dose-dependently relax the sustained contraction induced by PE in aortic rings. (a) The vasorelaxant effect of ZYZ-803 on the sustained contraction induced by PE was endothelium-dependent. The vasorelaxant effect of ZYZ-803 (b), the vasorelaxant effect of SPRC (c), the vasorelaxant effect of furoxan (d), and the vasorelaxant effect of the mixture of SPRC and furoxan (e) on the sustained contraction induced by PE in endothelium-contained aortic rings. Data represent mean ± SEM, for each group.

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(b)

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