Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway

Figure 6

ZYZ-803 relaxed aortic rings on PE-induced contractions through cGMP pathway. (a) The ZYZ-803-induced cGMP increase was abolished after L-NAME, PAG, and L-NAME + PAG treatments. (b) The vasorelaxant effect of ZYZ-803 on PE-induced contractions was suppressed after KT5823 treatment in aortic rings. (c) The expression level of VASP and p-VASP in aortic rings. Data represent mean ± SEM, for each group. compared with control group. compared with ZYZ-803 group.

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