Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

Table 2

Genotype frequencies of the polymorphisms studied in diabetic patients and controls.

Gene/polymorphism	Genotypes alleles	Diabetes	Controls	OR (95% CI)		of HWE
TXNIP; rs7211	CC, (%)	345 (55.4)	528 (54.5)	Reference		0.880
	CT, (%)	239 (38.3)	376 (38.8)	0.88 (0.6–1.3)	0.577
	TT, (%)	39 (6.3)	65 (6.7)	0.9 (0.8–1.2)	0.776
NQO1; rs1800566	CC, (%)	216 (34.7)	327 (33)	Reference		0.406
	CT, (%)	288 (46.2)	483 (48.6)	0.90 (0.7–1.1)	0.373
	TT, (%)	119 (19.1)	183 (18.4)	0.98 (0.7–1.3)	0.915
HMOX1; rs2071749	AA, (%)	269 (43.8)	413 (43.2)	Reference		0.625
	AG, (%)	267 (43.5)	417 (43.6)	1.05 (0.76–1.4)	0.757
	GG, (%)	78 (12.7)	126 (13.2)	1.03 (0.74–1.4)	0.837
NRF2; rs2364723	CC, (%)	210 (33.6)	301 (30.3)	Reference		0.092
	CG, (%)	286 (56.8)	471 (47.5)	0.87 (0.7–1.1)	0.236
	GG, (%)	129 (20.6)	220 (22.2)	0.84 (0.63–1.1)	0.223
NRF2; rs6721961	CC, (%)	407 (65.3)	618 (62.5)	Reference		0.281
	CA, (%)	189 (30.4)	317 (32)	0.9 (0.7–1.1)	0.374
	AA, (%)	27 (4.3)	54 (5.5)	0.76 (0.5–1.2)	0.259

CI, confidence interval; HWE, Hardy-Weinberg equilibrium; HMOX1, heme oxygenase-1; NQO1, NAD(P)H quinone oxidoreductase 1; NRF2, Nuclear factor-erythroid 2- (NF-E2-) related factor 2; OR, odds ratio; and TXNIP, thioredoxin interacting protein.