Oxidative Medicine and Cellular Longevity / 2016 / Article / Tab 3 / Research Article
Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients Table 3 Genotype and allele frequencies of the polymorphisms studied in obese and nonobese subjects.
Gene/polymorphism Genotype Obesity No obesity OR (95% CI) TRXNIP rs7211 CC, n (%) 350 (56.6) 523 (53.7) Reference CT, n (%) 239 (38.7) 376 (38.6) 0.95 (0.7–1.2) 0.627 TT, n (%) 29 (4.7) 75 (7.7) 0.56 (0.35–0.87) 0.012 NQO1 rs1800566 CC, n (%) 212 (34.2) 331 (33.3) Reference CT, n (%) 302 (48.8) 469 (47) 1 (0.8–1.25) 0.963 TT, n (%) 106 (17) 196 (19.7) 0.84 (0.6–1.1) 0.257 HMOX1 rs2071749 AA, n (%) 261 (40) 419 (45.7) Reference AG, n (%) 306 (46.9) 378 (41.3) 1.3 (1–1.6) 0.019 GG, n (%) 85 (13.1) 119 (13) 1.1 (0.8–1.5) 1.14 NRF2 rs2364723 CC, n (%) 194 (31) 317 (32) Reference CG, n (%) 300 (48) 457 (46) 1.1 (0.85–1.35) 0.551 GG, n (%) 131 (21) 210 (22) 0.98 (0.7–1.3) 0.899 NRF2 rs6721961 CC, n (%) 390 (63.1) 635 (63.9) Reference CA, n (%) 195 (31.6) 311 (31.3) 1 (0.8–1.3) 0.853 AA, n (%) 33 (5.3) 48 (4.8) 1.1 (0.7–1.7) 0.631
CI, confidence interval; HMOX1, heme oxygenase-1; NQO1, NAD(P)H quinone oxidoreductase 1; NRF2, Nuclear factor-erythroid 2- (NF-E2-) related factor 2; OR, odds ratio; and TXNIP, thioredoxin interacting protein.