Nutrients, Microglia Aging, and Brain Aging

Figure 1

A schematic representation of the preventing and reversal of microglia aging by the antioxidant nutrients. Increased microglial mitochondria-derived ROS induce neuroinflammation which initiates cognitive decline during aging. Chronic systemic inflammation promotes microglia aging even in middle age through excessive neuroinflammation. The oral intake of antioxidant nutrients, including propolis, RNSP, vitamins, and omega-3 fatty acids, will prevent and reverse microglia aging, thereby improving cognitive function and slowing brain aging.