AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

Figure 10

AP39 reduced Aβ production and Aβ deposition in APP/PS1 mice. (a)-(b) After intraperitoneal injection of AP39 for 6 weeks, Aβ₄₀ and Aβ₄₂ levels in the mouse brains were decreased from 925 pg/mL and 532 pg/mL to 531 pg/mL and 365 pg/mL, respectively. (c) Aβ plaques were detected in the cortex and the hippocampus of the WT and APP/PS1 mouse brains based on 6E10 immunostaining. The statistical results show the area of the Aβ plaques. Original magnification: –40x; scale bars = 100 μm.

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