AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

Figure 6

AP39 reduced the expression of proteins involved in mitochondrial fusion but increased the expression of a mitochondrial fission protein. (a) Protein samples were probed for Drp1, Fis1, Mfn1, Mfn2, OPA-1, and VDAC expression. (b–f) Representative blots are shown with quantification. AD mice receiving water compared to WT mice receiving water; mice receiving AP39 compared with mice receiving water.

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