Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity
Table 2
Changes in the levels of serotonin, GSH, and MDA and the activities of AchE, GPX, SOD, CAT, and LDH in brain extract of different experimental groups.
Parameters
Experimental groups
Control
Triton
GSE + triton
GSE + triton + B6
B6 + triton
AchE
21.34 ± 0.33
35.38 ± 0.22
22.91 ± 0.21
21.28 ± 0.39
23.90 ± 0.28
65.8%
7%
−0.28%
12%
Serotonin
350.70 ± 0.61
132.56 ± 0.26
280.88 ± 2.23
252.52 ± 0.40
232.22 ± 0.33
−62%
−20%
−28%
−33.8%
GSH
50.26 ± 0.24
23.84 ± 0.38
42.14 ± 0.17
49.76 ± 0.14
43.23 ± 0.17
−52.6%
−16%
−1%
−14%
GPX
53.99 ± 0.18
19.24 ± 0.29
41.08 ± 0.27
56.08 ± 0.27
45.85 ± 0.28
−64%
−24%
3.9%
−15%
SOD
65.64 ± 0.28
26.75 ± 0.13
51.08 ± 0.26
60.16 ± 0.32
52.60 ± 0.25
−59%
−22%
−0.1%
−20%
CAT
60.55 ± 0.26
16.14 ± 0.41
52.90 ± 0.19
58.15 ± 0.35
47.63 ± 0.37
−89.9%
−12.6%
−4%
−21%
MDA
24.84 ± 0.11
76.24 ± 0.21
34.60 ± 0.39
28.44 ± 0.25
36.86 ± 0.17
206.9%
39%
14%
48%
LDH
113.20 ± 0.42
37.69 ± 0.30
95.94 ± 0.11
101.46 ± 0.15
93.44 ± 0.28
−66.7%
−15%
−10%
−17%
Values are expressed as means ± SE. The mean values are significantly different in comparison with the control group at . The mean values are significantly different in comparison with the triton-intoxicated group at . A: mol substrate hydrolyzed/min/mg protein, B: ng/g tissue, C: mol/g tissue, D: U/mg protein, E: nmol/g tissue, and F: mg/g tissue.
