Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure

Figure 6

Protective effects of açaí supplementation in neuron-like cells SH-SY5Y exposed to rotenone. ① Rotenone causing mitochondrial complex I dysfunction, increasing superoxide production, and decreasing ATP synthesis; ② açaí freeze-dried hydroalcoholic extract supplementation acting at cell nucleus; ③ açaí freeze-dried hydroalcoholic extract increasing NDUFS7 and NDUFS8 gene expression in particular; ④ NDUFS7 and NDUFS8 protein production in response to the gene overexpression; ⑤ mitochondrial complex I assembly by new protein subunits; ⑥ renormalization of the mitochondrial electron transport chain, decreasing the oxidative stress, and normalizing ATP synthesis. ⑦ Decreased lipid peroxidation in consequence of the oxidative metabolism balance recovery.