Effects of Hyperoxia on Oxygen-Related Inflammation with a Focus on Obesity

Figure 1

Effects of obesity on adipose tissue. Oxidative stress, altered PO₂, and endoplasmic reticulum stress are potential triggering factors for metaflammation development. This chronic low-grade inflammation is associated with proinflammatory adipokines release and the concomitant macrophages migration to metaflammation zone. And, then, positive feedback for proinflammatory signals is perpetuated in the tissue which could be related to posterior metabolic disorders. IL-1β: Interleukin-1β; IL-6: Interleukin-6; TNF-α: tumor necrosis factor-α; LEP: leptin; MS: metabolic syndrome; CVD: cardiovascular disease; IR: insulin resistance.