Research Article
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis
Figure 1
Mesenchymal stem cells (MSCs) administration inhibits the decreased muscle strength induced by a high fat diet (HFD) in mice. C57BL/10J male mice were fed with a standard chow (control) or HFD for 38 weeks. At week 30, a subgroup of HFD mice received MSC injected through the tail-vein. At week 38, all mice were subjected to the following: (a) A weightlifting test to determine limb muscle strength: values represent the percentage of muscle strength reached by the mice with each weight and correspond to the mean ± SD (; versus control; versus HFD, two-way ANOVA). (b) A weightlifting test: the values represent the scores normalized by body weight. The values correspond to the mean ± SD (; versus control; versus HFD, two-way ANOVA). (c) Maximal isometric strengths (mN/mm2) against stimulation frequencies (Hz) in the tibialis anterior (TA) muscles: values represent the mean ± SD (; versus HFD, two-way ANOVA).
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