Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice

Figure 9

MaR 1 significantly inhibited NF-κB p65 subunit translocation into the nucleus. (a) The cytoplasmic NF-κB p65 subunit decreased in the CCl4 group but markedly increased with treatment of MaR 1. (b) Levels of nuclear NF-κB p65 were promoted in the CCl4 group but significantly deceased with treatment of MaR 1. (c) Levels of IκB-α in cytoplasm decreased after CCl4 administration but increased with treatment of MaR 1. A representative result from six independent experiments is shown. Quantification of cytoplasmic and nuclear NF-κB p65 (a and b) bands from the experiments was normalized by β-actin or lamin B1. The control group is set as 1.0. Data are expressed as means ± SEM. versus the control group, versus the CCl4 treated group.

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